APVV Projects

National

Drobné cicavce ako potenciálny zdroj zoonotických bakterií a rezistencie na antibiotiká
Small mammals as a potential source of zoonotic bacteria and resistance to antibiotics
Program: SRDA
Project leader: MVDr. Derdáková Markéta PhD.
Duration: 1.7.2015 – 30.6.2019
Funkcia neuropeptidov a ich receptorov pri regulácii prenosu patogénov z kliešťov na hostiteľa
The role of neuropeptides and receptors in regulation of pathogen transfer from ticks to their hosts
Program: SRDA
Project leader: RNDr. Žitňan Dušan DrSc.
Annotation: Ticks are very important vectors of dangerous pathogens, but regulatory mechanisms required for their successful transmission into the host are poorly understood. Likewise, physiological processes controlling function of the salivary glands, gut and gonads during their life cycle have not been elucidated. Our published and preliminary data indicate that several specific peptidergic neurons innervate these organs which are the most important reservoirs of pathogens. Our unpublished experiments suggest that identified neurons control activity of these organs and associated transmission of pathogens during tick feeding on the host. In this project we will use a combination of techniques (immunohistochemistry, molecular biology and bioinformatics) to identify regulatory molecules (neuropeptide and their receptors) and neuronal pathways important for normal function ofthe salivary glands, digestive system and reproductive organs of the ticks Ixodes ricinus and I. scapularis. We also propose to study the role of specific neuropeptides and their receptors in transmission of pathogens(Rickettsia helvetica and Borrelia burgdorferi) from these tick organs into laboratory mice using RNAi techniques. Expected results may provide tools for effective suppression of pathogen transmission and development of procedures to inhibit reproductive capability of ticks as dangerous ectoparasites of humans and animals.
Duration: 1.7.2015 – 30.6.2019
tsetse SIT – Zníženie plodnosti a kontrola trypanozomiáz bodaviek tsetse aplikáciou metód sterility a molekulárnych metód.
Reduction of fecundity and trypanosomiasis control of tsetse flies by the application of sterile insect techniques and molecular methods
Program: SRDA
Project leader: RNDr. Takáč Peter CSc.
Duration: 1.7.2016 – 30.6.2019
FLYFREEFARM – Bezpesticídová kontrola populácií muchy domácej a bodavky stajňovej v chovoch hospodárskych zvierat na Slovensku
Pesticide-free control of the house fly and stable fly populations on livestock farms in Slovakia
Program: SRDA
Project leader: RNDr. Kozánek Milan CSc.
Duration: 1.7.2015 – 30.6.2018
BIOFARTIS – Biologický význam a farmakologické vlastnosti proteínov v slinách kliešťov
Biological significance and pharmacological features of proteins in tick saliva
Program: SRDA
Project leader: RNDr. Kazimírová Mária CSc.
Duration: 1.10.2013 – 30.9.2017